Clinical and biochemical phenotypes in cardiorespiratory comorbidity

Objective: to estimate the incidence of recurrent myocardial infarction, stroke, and mortality in patients with different phenotypes infarction against background chronic obstructive pulmonary disease. Materials methods: 325 were examined: 195 disease 130 without We studied markers endogenous intoxication: molecules average mass, hematological indexes intoxication, blood gas composition, apoptosis, protein peroxidation, lipid antioxidant protection, inflammation renal function. Statistical processing data was performed using SPSS 26.0 software package. Results: A two-stage cluster analysis formed four clusters, which labeled as «polymarker-retentive», «necrotic-inflammatory», «hypoxic-inflammatory», a no intoxication syndrome. Among disease, hypoxic-inflammatory phenotype prevailed — 53.3 % patients. Necrotic-inflammatory noted 8.2 patients, 36.9% absence syndrome 1.5 Recurrent stroke constituted combined endpoint. The highest endpoint observed polymarker-retentive infarct 37 (55.2 %) Conclusion: Vascular life-threatening fatal events (recurrent death from cardiac causes) during 12-month follow-up are most typical for phenotype. clinical features this frequent presence Q-shaped MI, transmural damage, complications acute period. COPD these characterized by long course, high smoker's index, mostly 3 rd degree bronchoobstruction, exacerbations. results study allow personalized approach assessment annual prognosis COPD.